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Accueil du site > Productions scientifiques > Faits marquants > 2016 > Lab Chip - 2016 - Calcium oxalate precipitation by diffusion using laminar microfluidics : toward a biomimetic model of pathological microcalcifications

Lab Chip - 2016 - Calcium oxalate precipitation by diffusion using laminar microfluidics : toward a biomimetic model of pathological microcalcifications

par Ali Abou-Hassan - 29 mars 2016

Calcium oxalate precipitation by diffusion using laminar microfluidics : toward a biomimetic model of pathological microcalcifications

by : G. Laffite, C. Leroy, C. Bonhomme, L. Bonhomme-Coury, E. Letavernier, M. Daudon, V. Frochot, J. P. Haymann, S. Rouzière, I. T. Lucas, D. Bazin, F. Babonneau and A. Abou-Hassan

Contact PHENIX : ali.abou_hassan@upmc.fr

Abstract :

The effect of mixing calcium and oxalate precursors by diffusion at miscible liquid interfaces on calcium oxalate crystalline phases, and in physiological conditions (concentrations and flow rates), is studied using a microfluidic channel. This channel has similar dimensions as the collection duct in human kidneys and serves as a biomimetic model in order to understand the formation of pathological microcalcifications.